PT-141
Sold as: Vyleesi (bremelanotide)
A lab-made ring-shaped peptide that acts on brain receptors linked to sexual desire. Approved in the US for one group of women.
What it's made of
Ac-[Nle] then a ring of D H [D-Phe] R W K. Two lab-made blocks, a capped start, and a ring that makes it last longer.
Load it in the Peptide builder →Where it comes from
Copies part of alpha-MSH, a natural hormone that affects skin color and appetite. A close cousin of Melanotan II. Developed by Palatin Technologies.
What it's studied for
- ● Proven in humans
Approved in the US (2019) for low sexual desire causing distress in premenopausal women. Not approved for men or to boost performance.
- ● Proven in humans
In two trials of about 1,250 women, desire rose a little more than on placebo. The number of satisfying sexual events did not change.
Studied for ≠ proven to work. Check the stamp.
What we don't know
- ?
Nausea is very common: 40% versus 1.3% on placebo. Flushing and headache are also common.
- ?
Each use briefly raises blood pressure. Not for people with uncontrolled high blood pressure or heart disease.
- ?
It can darken the skin on the face and gums, and this may not fully go away.
Status
- Approved in the US only.
- Vietnam: no registration found.
- Sport: not named on the 2026 banned list.